Paradoxical effect (Eagle phenomenon)This occurs when, in tests to determine the MBC of an anti-biotic, organisms survive in signi¢cantly larger numbers on subculture from media containing antibiotic concentrationsabove, but not immediatelyabove, the MBC.
這句話翻成中文是說?作者: lcm3647 時間: 2005-2-14 21:03 標題: Re: Paradoxical effect (Eagle phenomenon The so-called `paradoxical effect`, whereby antibiotics exhibit reduced bactericidal activities at high drug concentrations, has been observed mainly, although not exclusively, with ß-lactams and Gram-positive bacteria. The phenomenon was first described by Eagle & Musselman who found that Staphylococcus aureus, ß-haemolytic streptococci and, most strikingly, Enterococcus faecalis were killed much more slowly by high concentrations of benzylpenicillin than by lower (but still supra-MIC) concentrations.
first described: Eagle, H. & Musselman, A. D. (1948). The rate of bactericidal action of penicillin in vitro as a function of its concentration, and its paradoxically reduced activity at high concentrations against certain organisms. Journal of Experimental Medicine 88, 99–131.