Paradoxical effect (Eagle phenomenon

gobf123

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Paradoxical effect (Eagle phenomenon)This occurs when, in tests to determine the MBC of an anti-biotic, organisms survive in signi¢cantly larger numbers on subculture from media containing antibiotic concentrationsabove, but not immediatelyabove, the MBC.

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lcm3647

The so-called `paradoxical effect`, whereby antibiotics exhibit reduced bactericidal activities at high drug concentrations, has been observed mainly, although not exclusively, with ß-lactams and Gram-positive bacteria. The phenomenon was first described by Eagle & Musselman who found that Staphylococcus aureus, ß-haemolytic streptococci and, most strikingly, Enterococcus faecalis were killed much more slowly by high concentrations of benzylpenicillin than by lower (but still supra-MIC) concentrations.

first described: Eagle, H. & Musselman, A. D. (1948). The rate of bactericidal action of penicillin in vitro as a function of its concentration, and its paradoxically reduced activity at high concentrations against certain organisms. Journal of Experimental Medicine 88, 99–131.

from: J Antimicrob Chemother 1999; 44: 418–420

[ Last edited by lcm3647 on 2005-2-14 at 21:04 ]